Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives

被引：16

作者：

Flekhter, OB

Boreko, EI

Nigmatullina, LR

Tret'yakova, EV

Pavlova, NI

Baltina, LA

Nikolaeva, SN

Savinova, OV

Galin, FZ

Tolstikov, GA

机构：

[1] Russian Acad Sci, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Russia

[2] State Res Inst Epidemiol & Microbiol, Minsk, BELARUS

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2003年 / 29卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

antiviral activity; betulinic acid; isocyanates; carbamates; ureides; lupane triterpenoids;

D O I：

10.1023/B:RUBI.0000008902.36604.97

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus.

引用

页码：594 / 600

页数：7

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