Engineered T cells and their therapeutic applications in autoimmune diseases

被引：19

作者：

Bao, Lei ^{[1
]}

Bo, Xiao-Chen ^{[1
]}

Cao, Huai-Wen ^{[1
]}

Qian, Chen ^{[1
]}

Wang, Zeng ^{[1
]}

Li, Bin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China

来源：

ZOOLOGICAL RESEARCH | 2022年 / 43卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Chimeric antigen receptor T cells; Cell immunotherapy; Autoimmune diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-CELL; RHEUMATOID-ARTHRITIS; PEMPHIGUS-VULGARIS; CD19; CAR; CLINICAL DEVELOPMENT; MICROSCOPIC COLITIS; GENE-TRANSFER; IN-VITRO; ANTIGEN;

D O I：

10.24272/j.issn.2095-8137.2021.363

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.

引用

页码：150 / 165

页数：16

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