Engineered T cells and their therapeutic applications in autoimmune diseases

被引：18
作者：
Bao, Lei [1 ]
Bo, Xiao-Chen [1 ]
Cao, Huai-Wen [1 ]
Qian, Chen [1 ]
Wang, Zeng [1 ]
Li, Bin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China
来源：
ZOOLOGICAL RESEARCH | 2022年 / 43卷 / 02期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Chimeric antigen receptor T cells; Cell immunotherapy; Autoimmune diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; B-CELL; RHEUMATOID-ARTHRITIS; PEMPHIGUS-VULGARIS; CD19; CAR; CLINICAL DEVELOPMENT; MICROSCOPIC COLITIS; GENE-TRANSFER; IN-VITRO; ANTIGEN;
D O I：
10.24272/j.issn.2095-8137.2021.363
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.
引用
收藏
页码：150 / 165
页数：16
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