Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance

被引：55

作者：

Bai, Haotian ^{[1
]}

Lv, Fengting ^{[1
]}

Liu, Libing ^{[1
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 32期

基金：

中国国家自然科学基金;

关键词：

antibiotics; drug resistance; host guest systems; photochemical switches; supramolecular chemistry; GOLD NANOPARTICLES; CUCURBITURIL HOMOLOGS; MOLECULAR CONTAINERS; BIOCIDAL ACTIVITY; CHEMISTRY; BACTERIA; CATALYSIS; DISCOVERY; POLYMERS; SYSTEMS;

D O I：

10.1002/chem.201600877

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bacterial infectious disease is a serious public health concern throughout the world. Pathogen drug resistance, arising from both rational use and abuse/misuse of germicides, complicates the situation. Aside from developing novel antibiotics and antimicrobial agents, molecular approaches have become another significant method to overcome the problem of pathogen drug resistance. Established supramolecular systems, the antibiotic properties of which can be switched "on" and "off" through host-guest interactions, show great potential in combating issues regarding antibiotic resistance in the long term, as indicated by several recent studies. In this Concept, recently developed strategies for antibacterial regulation are summarized and further directions for research into antibiotic switches are proposed.

引用

页码：11114 / 11121

页数：8

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