Circuit organization of sugar reinforcement

被引：29

作者：

de Araujo, Ivan E. ^{[1
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机构：

[1] John B Pierce Lab, 290 Congress Ave, New Haven, CT 06519 USA

[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[3] Yale Univ, Dept Physiol, Sch Arts & Sci, New Haven, CT USA

[4] Yale Univ, Sch Med, 290 Congress Ave, New Haven, CT 06519 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2016年 / 164卷

关键词：

Dopamine; Drosophila; Mouse; Reward; Sugar; Sweetness; BASAL GANGLIA; STRIATAL NEURONS; DOPAMINE; DROSOPHILA; TASTE; REWARD; SELECTION; SYSTEMS; CONNECTIONS; MODULATION;

D O I：

10.1016/j.physbeh.2016.04.041

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Sugar's potent reinforcing properties arise from the complex interplay between gustatory and nutritive signals. This commentary addresses a unique organizational aspect of the neuronal circuitry that mediates sugar reinforcement in both Drosophila and rodents. Specifically, current evidence supports a general circuit model where separate populations of dopaminergic neurons encode the gustatory and nutritive values of sugar. This arrangement allows animals to prioritize energy seeking over taste quality, and implies that specialized subpopulations of dopamine-containing neurons form a class of evolutionary conserved chemo-and nutrient-sensors. 2016 Elsevier Inc. All rights reserved.

引用

页码：473 / 477

页数：5

共 39 条

[1] Post-oral infusion sites that support glucose-conditioned flavor preferences in rats [J].

Ackroff, Karen ;

Yiin, Yeh-Min ;

Sclafani, Anthony .

PHYSIOLOGY & BEHAVIOR, 2010, 99 (03) :402-411

[2] Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia [J].

Bohland, MaryAnn ;

Matveyenko, Aleksey V. ;

Saberi, Maziyar ;

Khan, Arshad M. ;

Watts, Alan G. ;

Donovan, Casey M. .

DIABETES, 2014, 63 (08) :2866-2875

[3]

Burke C.J., 2012, NATURE

[4] Food reward in the absence of taste receptor signaling [J].

de Araujo, Ivan E. ;

Oliveira-Maia, Albino J. ;

Sotnikova, Tatyana D. ;

Gainetdinov, Raul R. ;

Caron, Marc G. ;

Nicolelis, Miguel A. L. ;

Simon, Sidney A. .

NEURON, 2008, 57 (06) :930-941

[5] The gut-brain dopamine axis: A regulatory system for caloric intake [J].

de Araujo, Ivan E. ;

Ferreira, Jozelia G. ;

Tellez, Luis A. ;

Ren, Xueying ;

Yeckel, Catherine W. .

PHYSIOLOGY & BEHAVIOR, 2012, 106 (03) :394-399

[6] Portal glucose influences the sensory, cortical and reward systems in rats [J].

Delaere, Fabien ;

Akaoka, Hideo ;

De Vadder, Filipe ;

Duchampt, Adeline ;

Mithieux, Gilles .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2013, 38 (10) :3476-3486

[7] Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila [J].

Dus, Monica ;

Lai, Jason Sih-Yu ;

Gunapala, Keith M. ;

Min, Soohong ;

Tayler, Timothy D. ;

Hergarden, Anne C. ;

Geraud, Eliot ;

Joseph, Christina M. ;

Suh, Greg S. B. .

NEURON, 2015, 87 (01) :139-151

[8] Taste-independent detection of the caloric content of sugar in Drosophila [J].

Dus, Monica ;

Min, SooHong ;

Keene, Alex C. ;

Lee, Ga Young ;

Suh, Greg S. B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11644-11649

[9] Dopamine Differentially Modulates the Excitability of Striatal Neurons of the Direct and Indirect Pathways in Lamprey [J].

Ericsson, Jesper ;

Stephenson-Jones, Marcus ;

Perez-Fernandez, Juan ;

Robertson, Brita ;

Silberberg, Gilad ;

Grillner, Sten .

JOURNAL OF NEUROSCIENCE, 2013, 33 (18) :8045-+

[10] Neural systems of reinforcement for drug addiction: from actions to habits to compulsion [J].

Everitt, BJ ;

Robbins, TW .

NATURE NEUROSCIENCE, 2005, 8 (11) :1481-1489

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