Signaling clusters in the cell membrane

被引:112
作者
Hartman, Nina C. [1 ,2 ]
Groves, Jay T. [3 ,4 ]
机构
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA
[3] Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA USA
[4] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA USA
关键词
NATURAL-KILLER-CELL; IMMUNOLOGICAL SYNAPSE; ACTIN CYTOSKELETON; RECEPTOR; ACTIVATION; COMPLEX; ANTIGEN; TCR; MICROCLUSTERS; TRANSDUCTION;
D O I
10.1016/j.ceb.2011.05.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Large-scale molecular assemblies, or signaling clusters, at the cell membrane are emerging as important regulators of cell signaling. Here, we review new findings and describe shared characteristics common to signaling clusters from a diverse set of cellular systems. The well-known T cell receptor cluster serves as our paradigmatic model. Specifically, each cluster initiates recruitment of hundreds of molecules to the membrane, interacts with the actin cytoskeleton, and contains a significant fraction of the entire signaling process. Probed by recent advancements in patterning and microscopy techniques, the signaling clusters display functional outcomes that are not readily predictable from the individual components.
引用
收藏
页码:370 / 376
页数:7
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