adenosine 5 '-triphosphate;
purines;
group III afferents;
group IV afferents;
metaboreflex;
pressor response;
D O I:
10.1152/japplphysiol.01020.2003
中图分类号:
Q4 [生理学];
学科分类号:
071003 ;
摘要:
The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of alpha,beta-methylene ATP (50 mug/kg) was examined in decerebrate cats. We found that this P2X(3) agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by alpha,beta-methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by alpha,beta-methylene ATP. We conclude that P2X(3) agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.
机构:
Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, EnglandKings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Bradbury, EJ
Burnstock, G
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机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Burnstock, G
McMahon, SB
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
机构:
Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, EnglandKings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Bradbury, EJ
Burnstock, G
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England
Burnstock, G
McMahon, SB
论文数: 0引用数: 0
h-index: 0
机构:Kings Coll London, Guys Kings & St Thomas Sch Biomed Sci, London SE1 7EH, England