Activation of thin-fiber muscle afferents by a P2X agonist in cats

被引:61
作者
Hanna, RL
Kaufman, MP
机构
[1] Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med TB 172, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Human Physiol, Div Cardiovasc Med TB 172, Davis, CA 95616 USA
关键词
adenosine 5 '-triphosphate; purines; group III afferents; group IV afferents; metaboreflex; pressor response;
D O I
10.1152/japplphysiol.01020.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of alpha,beta-methylene ATP (50 mug/kg) was examined in decerebrate cats. We found that this P2X(3) agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by alpha,beta-methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by alpha,beta-methylene ATP. We conclude that P2X(3) agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.
引用
收藏
页码:1166 / 1169
页数:4
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