Microwave-Assisted Synthesis of d/l-Agrimonolide

被引：4
作者：
Cui, Yu-Ang [1 ,2 ]
Zhang, Guang-Yu [1 ,2 ]
Li, Yun-Zhi [1 ,2 ]
Li, Wei [1 ,2 ]
Tanabe, Genzoh [3 ]
Osamu, Muraoka [3 ]
Xie, Wei-Jia [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med SKLNM, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China
[3] Kinki Univ, Fac Pharm, 3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Agrimonolide; Cyclization; 3; 4-dihydroisocoumarin; Microwave assisted synthesis; Total synthesis; ISOCOUMARIN;
D O I：
10.1002/ajoc.202100334
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, we reported an improved approach for the synthesis of d/l Agrimonolide from 4-Chlororesorcinol. It was found that a microwave assisted intramolecular esterification is an effective way to construct the 3,4-dihydroisocoumarin core structure. The target d/l Agrimonolide is obtained in 7 steps with the overall yields of 20.7%.
引用
收藏
页数：4
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