Microwave-Assisted Synthesis of d/l-Agrimonolide

被引：4

作者：

Cui, Yu-Ang ^{[1
,2
]}

Zhang, Guang-Yu ^{[1
,2
]}

Li, Yun-Zhi ^{[1
,2
]}

Li, Wei ^{[1
,2
]}

Tanabe, Genzoh ^{[3
]}

Osamu, Muraoka ^{[3
]}

Xie, Wei-Jia ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med SKLNM, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

[3] Kinki Univ, Fac Pharm, 3-4-1 Kowakae, Higashiosaka, Osaka 5778502, Japan

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Agrimonolide; Cyclization; 3; 4-dihydroisocoumarin; Microwave assisted synthesis; Total synthesis; ISOCOUMARIN;

D O I：

10.1002/ajoc.202100334

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we reported an improved approach for the synthesis of d/l Agrimonolide from 4-Chlororesorcinol. It was found that a microwave assisted intramolecular esterification is an effective way to construct the 3,4-dihydroisocoumarin core structure. The target d/l Agrimonolide is obtained in 7 steps with the overall yields of 20.7%.

引用

页数：4

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