Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma

被引:12
作者
Sharbatoghli, Mina [1 ]
Shamshiripour, Parisa [1 ]
Fattahi, Fahimeh [1 ]
Kalantari, Elham [1 ]
Shams, Zohre Habibi [2 ]
Panahi, Mahshid [2 ]
Totonchi, Mehdi [3 ,4 ]
Asadi-Lari, Zeynab [5 ]
Madjd, Zahra [1 ]
Zanjani, Leili Saeednejad [1 ]
机构
[1] Iran Univ Med Sci IUMS, Oncopathol Res Ctr, Tehran, Iran
[2] Iran Univ Med Sci, Fac Med, Dept Pathol, Tehran, Iran
[3] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Stem Cells & Dev Biol, Cell Sci Res Ctr, Tehran, Iran
[4] ACECR, Reprod Biomed Res Ctr, Royan Inst Reprod Biomed, Dept Genet, Tehran, Iran
[5] Univ Toronto, Fac Sci, Dept Biol, Toronto, ON, Canada
关键词
Serous ovarian carcinoma (SOC); SALL4; Prognosis; Immunohistochemistry (IHC); Tissue microarray (TMA); ALDEHYDE DEHYDROGENASE; LUNG-CANCER; SALL4; EXPRESSION; PROGNOSIS; GRADE; CYTOSCAPE; BIOMARKER; PREDICTS; ALDH1A1;
D O I
10.1186/s13048-021-00921-x
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Spalt-like transcription factor 4 (SALL4) and aldehyde dehydrogenase1 family member A1 (ALDH1A1) expressing cells have been characterized as possessing stem cell-like properties known as cancer stem cell marker in serous ovarian carcinoma (SOC). Methods The association between SALL4 and ALDH1A1 was observed based on literature review and bioinformatics tools. Therefore, this study aimed to investigate the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in SOC patients using immunohistochemical staining on tissue microarrays (TMAs). Furthermore, benign tumors and normal tissue samples were compared with the expression of the tumor tissue samples. Results Increased co-expression of SALL4/ALDH1A1 was found to be significantly associated with the advanced FIGO stage (P = 0.047), and distant metastasis (P = 0.028). The results of Kaplan-Meier survival analysis indicated significant differences between disease- specific survival (DSS; P = 0.034) or progression-free survival (PFS; P = 0.018) and the patients with high and low co-expression of SALL4/ALDH1A1, respectively. Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis. The data also indicated that the co-expression of SALL4/ALDH1A1 was an independent prognostic factor affecting PFS. Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis. Conclusions Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients. Therefore, co-expression of SALL4/ALDH1A1 may serve as a potential prognostic biomarker of cancer progression in these cases.
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页数:17
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