IL-15 ENHANCES IN-VITRO EXPANSION AND FUNCTIONAL ACTIVITY OF ANTIGEN-SPECIFIC EFFECTOR MEMORY T CELLS (TEM) WHILE CO-EXPRESSION OF IL-15 AND IL-15 R ON ANTIGEN PRESENTING CELLS ALSO PROMOTES ENRICHMENT AND PREFERENTIAL EXPANSION OF CENTRAL MEMORY T-CELLS (TCM)

被引:1
|
作者
Hasan, A. N.
Selvakumar, A.
Liu, X. -R.
Sadelain, M. W.
Riviere, I.
Dupont, B.
O'Reilly, R. J.
机构
关键词
D O I
10.1016/j.bbmt.2009.12.025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
13
引用
收藏
页码:S159 / S159
页数:1
相关论文
共 50 条
  • [21] IL-7 and IL-15 are essential for the proliferation and survival of memory CD8 T cells
    Sivakumar, PV
    Glaccum, M
    Kennedy, M
    Bevan, M
    Benoist, C
    Mathis, D
    Butz, E
    Goldrath, A
    JOURNAL OF LEUKOCYTE BIOLOGY, 2001, : 101 - 101
  • [22] IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
    Younes, Souheil-Antoine
    Freeman, Michael L.
    Mudd, Joseph C.
    Shive, Carey L.
    Reynaldi, Arnold
    Panigrahi, Soumya
    Estes, Jacob D.
    Deleage, Claire
    Lucero, Carissa
    Anderson, Jodi
    Schacker, Timothy W.
    Davenport, Miles P.
    McCune, Joseph M.
    Hunt, Peter W.
    Lee, Sulggi A.
    Serrano-Villar, Sergio
    Debernardo, Robert L.
    Jacobson, Jeffrey M.
    Canaday, David H.
    Sekaly, Rafick-Pierre
    Rodriguez, Benigno
    Sieg, Scott F.
    Lederman, Michael M.
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (07): : 2745 - 2756
  • [23] Eradication of neuroblastoma by T-cells redirected with an optimized GD2-specific chimeric antigen receptor and IL-15
    Chen, Yuhui
    Sun, Chuang
    Metelitsa, Leonid
    Dotti, Gianpietro
    Savoldo, Barbara
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (02)
  • [24] An In-Vitro Study of the Expansion and Transcriptomics of CD4+ and CD8+ Naive and Memory T Cells Stimulated by IL-2, IL-7 and IL-15
    Hopkins, Brooks
    Fisher, Justin
    Chang, Meiping
    Tang, Xiaoyan
    Du, Zhimei
    Kelly, William J.
    Huang, Zuyi
    CELLS, 2022, 11 (10)
  • [25] IL-7 and IL-15 rapidly induce memory-like CD8+T cells in vitro
    Carrio, R
    Bathe, OF
    Malek, TR
    FASEB JOURNAL, 2003, 17 (07): : C5 - C5
  • [26] Co-expression of IL-15 and IL-15Rα on pancreatic β islet cells induced insulin dependent diabetes mellitus in mice
    Chen, Jing
    Feigenbaum, Lionel
    Awasthi, Parirokh
    Butcher, Donna
    Anver, Miriam
    Bamford, Richard
    Thomas, Craig
    Waldmann, Thomas
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [27] Expression of an IL-15 receptor fusion protein enhances the persistence of TRuC-T cells
    Fleury, Michelle
    Anderson, Courtney
    Watt, Amy
    Horton, Holly
    Zieba, Adam
    Ding, Jian
    Tighe, Robert
    Hofmeister, Robert
    McCarthy, Derrick
    Gutierrez, Dario
    CANCER IMMUNOLOGY RESEARCH, 2022, 10 (01)
  • [28] Trispecific Killer Engagers (TriKEs) that contain IL-15 to make NK cells antigen specific and to sustain their persistence and expansion
    Miller, Jeffrey S.
    Felice, Martin
    McElmurry, Ron
    McCullar, Valerie
    Zhou, Xianzheng
    Tolar, Jakub
    Schmohl, Joerg Uwe
    Panoskaltsis-Mortari, Angela
    Zhang, Bin
    Taras, Elizabeth
    Verneris, Michael R.
    Cooley, Sarah
    Weisdorf, Daniel J.
    Blazar, Bruce R.
    Vallera, Dan
    BLOOD, 2015, 126 (23)
  • [29] Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
    Xu, Yang
    Zhang, Ming
    Ramos, Carlos A.
    Durett, April
    Liu, Enli
    Dakhova, Olga
    Liu, Hao
    Creighton, Chad J.
    Gee, Adrian P.
    Heslop, Helen E.
    Rooney, Cliona M.
    Savoldo, Barbara
    Dotti, Gianpietro
    BLOOD, 2014, 123 (24) : 3750 - 3759
  • [30] Configuration-dependent Presentation of Multivalent IL-15: IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity
    Hong, Enping
    Usiskin, Ilana M.
    Bergamaschi, Cristina
    Hanlon, Douglas J.
    Edelson, Richard L.
    Justesen, Sune
    Pavlakis, George N.
    Flavell, Richard A.
    Fahmy, Tarek M.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (17) : 8931 - 8950