SYNTHESIS AND ANTIDIABETIC ACTIVITY OF THIAZOLO[2,3-f]PURINE DERIVATIVES AND THEIR ANALOGS

被引：5

作者：

Spasov, A. A. ^{[1
]}

Khaliullin, F. A. ^{[2
]}

Babkov, D. A. ^{[1
]}

Timirkhanova, G. A. ^{[2
]}

Kuznetsova, V. A. ^{[1
]}

Naumenko, L. V. ^{[1
]}

Muleeva, D. R. ^{[1
]}

Maika, O. Yu. ^{[1
]}

Prokhorova, T. Yu. ^{[1
]}

Sturova, E. A. ^{[1
]}

机构：

[1] Volgograd State Med Univ, Minist Hlth Russian Federat, Volgograd 400131, Russia

[2] Bashkir State Med Univ, Minist Hlth Russian Federat, Ufa 450008, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 07期

基金：

俄罗斯科学基金会;

关键词：

thietanes; purine; antidiabetic activity; INHIBITORS; XANTHINE;

D O I：

10.1007/s11094-017-1649-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiazolo[2, 3-f]purine derivatives and their analogs - dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives - were synthesized. The compounds synthesized here had no effects on protein glycation reactions using glucose; they gave weak inhibition of glycogen phosphorylase; they had no hemorheological activity. Substances with hypotensive activity greater than that of Dibazol were found. A number of substances had hypoglycemic effects greater than those of chlorpropamide and Adebit. Two compounds inhibited dipeptidylpeptidase-4, but were less active than reference agent vildagliptin.

引用

页码：533 / 539

页数：7