Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits

被引：83

作者：

Betley, J. Nicholas ^{[1
]}

Sternson, Scott M. ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Ashburn, VA 20147 USA

来源：

HUMAN GENE THERAPY | 2011年 / 22卷 / 06期

关键词：

GENETICALLY TARGETED NEURONS; MOUSE-BRAIN; TRANSGENE EXPRESSION; OPTOGENETIC CONTROL; GENE-EXPRESSION; VIRUS VECTORS; SELECTIVE EXPRESSION; LENTIVIRAL VECTORS; AAV VECTORS; CELL-TYPES;

D O I：

10.1089/hum.2010.204

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Understanding the structure and function of neural circuits is central is neuroscience research. To address the associated questions, new genetically encoded tools have been developed for mapping, monitoring, and manipulating neurons. Essential to implementation of these tools is their selective delivery to defined neuronal populations in the brain. This has been facilitated by recent improvements in cell type-specific transgene expression using recombinant adeno-associated viral vectors. Here, we highlight these developments and discuss areas for improvement that could further expand capabilities for neural circuit analysis.

引用

页码：669 / 677

页数：9

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