Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

被引：43
作者：
Blahak, Christian [1 ]
Capelle, Hans-Holger [2 ]
Baezner, Hansjoerg [1 ]
Kinfe, Thomas M. [2 ]
Hennerici, Michael G. [1 ]
Krauss, Joachim K. [2 ]
机构：
[1] Heidelberg Univ, Univ Med Mannheim UMM, Dept Neurol, D-68167 Mannheim, Germany
[2] MHH, Hannover Med Sch, Dept Neurosurg, Hannover, Germany
来源：
JOURNAL OF NEURAL TRANSMISSION | 2011年 / 118卷 / 04期
关键词：
Dystonia; Deep brain stimulation; Globus pallidus internus; Micrographia; Hypokinesia; DEEP-BRAIN-STIMULATION; GLOBUS-PALLIDUS; PARKINSONS-DISEASE; INFARCTION; INTERNUS; LESIONS;
D O I：
10.1007/s00702-010-0544-y
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.
引用
收藏
页码：549 / 553
页数：5
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