Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

被引：43

作者：

Seddon, Angela B. ^{[1
]}

Napier, Bruce ^{[2
]}

Lindsay, Ian ^{[3
,4
]}

Lamrini, Samir ^{[5
]}

Moselund, Peter M. ^{[6
]}

Stone, Nicholas ^{[7
]}

Bang, Ole ^{[8
]}

Farries, Mark ^{[9
]}

机构：

[1] Univ Nottingham, Fac Engn, George Green Inst Electromagnet Res, Midinfrared Photon Grp, Nottingham NG7 2RD, England

[2] Vivid Components Ltd, German Off, Dr Rorig Damm 22, D-33102 Paderborn, Germany

[3] Gooch & Housego, Ilminster, England

[4] Univ Bristol, HH Wills Phys Lab, Tyndall Ave, Bristol BS8 1TL, Avon, England

[5] LISA Laser Prod OHG, Fuhrberg & Teichmann, Albert Einstein Str 1-9, D-37191 Katlenburg Lindau, Germany

[6] NKT Photon AS, Blokken 84, DK-3460 Birkerod, Denmark

[7] Univ Exeter, Coll Engn Math & Phys Sci, Phys & Astron, Exeter EX4 4QL, Devon, England

[8] Tech Univ Denmark, DTU Fotonik, Fibre Sensors & Supercontinuum Grp, DK-2800 Lyngby, Denmark

[9] Gooch & Housego Torquay, Broomhill Way, Torquay TQ2 7QL, England

来源：

ANALYST | 2018年 / 143卷 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

INFRARED-SPECTROSCOPY; CHALCOGENIDE GLASSES; IR;

D O I：

10.1039/c8an01396a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 m wavelength to cover the spectral fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 m wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the fingerprint region'.

引用

页码：5874 / 5887

页数：14

共 39 条

[1]

Agger C., 2013, NONL OPT OSA OPT SOC, DOI [10.1364/NLO.2013.NW4A.09, DOI 10.1364/NLO.2013.NW4A.09]

[2] EMISSION IN REGION 4000 TO 7000 A VIA 4-PHOTON COUPLING IN GLASS [J].

ALFANO, RR ;

SHAPIRO, SL .

PHYSICAL REVIEW LETTERS, 1970, 24 (11) :584-&

[3]

[Anonymous], 1990, Fluoride Glass Optical Fibers

[4] Using Fourier transform IR spectroscopy to analyze biological materials [J].

Baker, Matthew J. ;

Trevisan, Julio ;

Bassan, Paul ;

Bhargava, Rohit ;

Butler, Holly J. ;

Dorling, Konrad M. ;

Fielden, Peter R. ;

Fogarty, Simon W. ;

Fullwood, Nigel J. ;

Heys, Kelly A. ;

Hughes, Caryn ;

Lasch, Peter ;

Martin-Hirsch, Pierre L. ;

Obinaju, Blessing ;

Sockalingum, Ganesh D. ;

Sule-Suso, Josep ;

Strong, Rebecca J. ;

Walsh, Michael J. ;

Wood, Bayden R. ;

Gardner, Peter ;

Martin, Francis L. .

NATURE PROTOCOLS, 2014, 9 (08) :1771-1791

[5]

Bellisola G, 2012, AM J CANCER RES, V2, P1

[6] Supercontinuum-based Fourier transform infrared spectromicroscopy [J].

Borondics, F. ;

Jossent, M. ;

Sandt, C. ;

Lavoute, L. ;

Gaponov, D. ;

Hideur, A. ;

Dumas, P. ;

Fevrier, S. .

OPTICA, 2018, 5 (04) :378-381

[7] Refractive index dispersion of chalcogenide glasses for ultra-high numerical-aperture fiber for mid-infrared supercontinuum generation [J].

Dantanarayana, Harshana G. ;

Abdel-Moneim, Nabil ;

Tang, Zhuoqi ;

Sojka, Lukasz ;

Sujecki, Slawomir ;

Furniss, David ;

Seddon, Angela B. ;

Kubat, Irnis ;

Bang, Ole ;

Benson, Trevor M. .

OPTICAL MATERIALS EXPRESS, 2014, 4 (07) :1444-1455

[8] Infrared spectroscopy of cells and tissues: Shining light onto a novel subject [J].

Diem, M ;

Boydston-White, S ;

Chiriboga, L .

APPLIED SPECTROSCOPY, 1999, 53 (04) :148A-161A

[9] Molecular pathology via IR and Raman spectral imaging [J].

Diem, Max ;

Mazur, Antonella ;

Lenau, Kathleen ;

Schubert, Jen ;

Bird, Ben ;

Miljkovic, Milos ;

Krafft, Christoph ;

Popp, Juergen .

JOURNAL OF BIOPHOTONICS, 2013, 6 (11-12) :855-886

[10] All-fiber chalcogenide-based mid-infrared supercontinuum source [J].

Gattass, Rafael R. ;

Shaw, L. Brandon ;

Nguyen, V. Q. ;

Pureza, P. C. ;

Aggarwal, Ishwar D. ;

Sanghera, Jasbinder S. .

OPTICAL FIBER TECHNOLOGY, 2012, 18 (05) :345-348

← 1 2 3 4 →