A feasibility investigation of mindfulness-based cognitive therapy for people with Huntington's disease

被引:12
作者
Eccles, Fiona J. R. [1 ]
Craufurd, David [2 ,3 ]
Smith, Alistair [1 ]
Davies, Rhys [4 ]
Glenny, Kristian [1 ]
Homberger, Max [1 ]
Peeren, Siofra [2 ,3 ]
Rogers, Dawn [2 ,3 ]
Rose, Leona [1 ]
Skitt, Zara [2 ,3 ]
Theed, Rachael [1 ]
Simpson, Jane [1 ]
机构
[1] Univ Lancaster, Fac Hlth & Med, Div Hlth Res, Lancaster LA1 4YT, England
[2] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Sci, Manchester M13 9PL, Lancs, England
[3] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Oxford Rd, Manchester M13 9WL, Lancs, England
[4] Walton Ctr NHS Fdn Trust, Lower Lane, Liverpool L9 7LJ, Merseyside, England
关键词
Huntington's disease; Mindfulness; Depression; Anxiety; Stress; QUALITY-OF-LIFE; BEHAVIORAL THERAPY; ILLNESS PERCEPTIONS; HOSPITAL ANXIETY; DEPRESSION SCALE; PILOT; VALIDATION; DISTRESS; MEDIATE; ADULTS;
D O I
10.1186/s40814-020-00631-z
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
BackgroundHuntington's disease (HD) is an inherited neurodegenerative condition which affects movement, coordination and cognitive functioning. Psychological difficulties are commonly experienced; however, psychological interventions have been little researched with this population. We investigated the feasibility of conducting a randomised controlled trial (RCT) of mindfulness-based cognitive therapy (MBCT) with people with the HD genetic mutation, either pre-manifest (before onset of movement symptoms) or at an early disease stage. Specifically, we evaluated the willingness of participants to be recruited into and complete the intervention; the acceptability of the study measures in relation to completion; the feasibility of offering the standard MBCT course to people with HD; the acceptability of the intervention and the estimated effect sizes.MethodsParticipants were recruited from two UK HD centres and took part in an 8-week course of MBCT, with three reunions throughout the following year. Stress, depression, anxiety, and mindfulness were measured pre-, mid-, and post-course, at 3months and at 1year. Sleep, quality of life, positive affect and coping were measured pre- and post-course, at 3months and at 1year. Descriptive data and approximate effect sizes were calculated. Interviews were conducted post-course and at 1year and data pertaining to the acceptability of the course were extracted.ResultsTwelve participants took part in two groups; all were pre-manifest. Levels of depression and anxiety were low pre-course leaving little room for improvement. Changes in stress and in some aspects of mindfulness were medium to large. The qualitative data suggested participants rated the course highly and found it helpful and no changes to the standard course were needed. Recruitment levels were below those anticipated. Most measures were found to be acceptable.ConclusionsAlthough the course was acceptable to those who took part, given the difficulties in recruiting and the rarity of HD, conducting an RCT of MBCT teaching groups in person does not seem feasible. However, alternative modes of course delivery (e.g. online) would allow the recruitment of people from a greater geographical area and may make an RCT feasible; this revised focus would be suitable for future feasibility studies.Trial registrationClinicalTrials.gov identifier NCT02464293, registered 8 June 2015.
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页数:13
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