Osteoconduction and osteoinduction of low-temperature 3D printed bioceramic implants

被引：248

作者：

Habibovic, Pamela ^{[1
,2
]}

Gbureck, Uwe ^{[3
]}

Doillon, Charles J. ^{[4
,5
]}

Bassett, David C. ^{[2
]}

van Blitterswijk, Clemens A. ^{[1
]}

Barralet, Jake E. ^{[2
]}

机构：

[1] Univ Twente, Inst Biomed Technol, Dept Tissue Regenerat, NL-7522 NB Enschede, Netherlands

[2] McGill Univ, Fac Dent, Montreal, PQ H3A 2B2, Canada

[3] ZMK Klin, Abt Funkt Werkstoffe, D-97070 Wurzburg, Germany

[4] Univ Laval, Dept Surg, Quebec City, PQ G1V 4G2, Canada

[5] CHU Laval, Res Ctr, Oncol & Mol Endocrinol Res Ctr, Quebec City, PQ G1V 4G2, Canada

来源：

BIOMATERIALS | 2008年 / 29卷 / 07期

关键词：

calcium phosphate cement; three dimensional printing; osteoconduction; osteoinduction; in vivo test;

D O I：

10.1016/j.biomaterials.2007.10.023

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Rapid prototyping is a valuable implant production tool that enables the investigation of individual geometric parameters, such as shape, porosity, pore size and permeability, on the biological performance of synthetic bone graft substitutes. In the present study, we have employed tow-temperature direct 3D printing to produce brushite and monetite implants with different geometries. Blocks predominantly consisting of brushite with channels either open or closed to the exterior were implanted on the decorticated lumbar transverse processes of goats for 12 weeks. In addition, similar blocks with closed channel geometry, consisting of either brushite or monetite were implanted intramuscularly. The design of the channels allowed investigation of the effect of macropore geometry (open and closed pores) and osteoinduction on bone formation orthotopically. Intramuscular implantation resulted in bone formation within the channels of both monetite and brushite, indicating osteoinductivity of these resorbable materials. Inside the blocks mounted on the transverse processes, initial channel shape did not seem to significantly influence the final amount of formed bone and osteoinduction was suggested to contribute to bone formation. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：944 / 953

页数：10

共 42 条

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