A decade of caspases

被引：948

作者：

Degterev, A ^{[1
]}

Boyce, M ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

ONCOGENE | 2003年 / 22卷 / 53期

关键词：

caspase; apoptosis; protease;

D O I：

10.1038/sj.onc.1207107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.

引用

页码：8543 / 8567

页数：25

共 321 条

[1] Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation [J].

Acehan, D ;

Jiang, XJ ;

Morgan, DG ;

Heuser, JE ;

Wang, XD ;

Akey, CW .

MOLECULAR CELL, 2002, 9 (02) :423-432

[2]

Ahmad M, 1998, CANCER RES, V58, P5201

[3]

Ahmad M, 1997, CANCER RES, V57, P615

[4] Human ICE/CED-3 protease nomenclature [J].

Alnemri, ES ;

Livingston, DJ ;

Nicholson, DW ;

Salvesen, G ;

Thornberry, NA ;

Wong, WW ;

Yuan, JY .

CELL, 1996, 87 (02) :171-171

[5]

An B, 1996, CANCER RES, V56, P438

[6] p53 inhibits α6β4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB [J].

Bachelder, RE ;

Ribick, MJ ;

Marchetti, A ;

Falcioni, R ;

Soddu, S ;

Davis, KR ;

Mercurio, AM .

JOURNAL OF CELL BIOLOGY, 1999, 147 (05) :1063-1072

[7] The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis [J].

Bachelder, RE ;

Wendt, MA ;

Fujita, N ;

Tsuruo, T ;

Mercurio, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34702-34707

[8]

BALIGA BC, 2002, J BIOL CHEM, V10, P10

[9] Evolutionary lines of cysteine peptidases [J].

Barrett, AJ ;

Rawlings, ND .

BIOLOGICAL CHEMISTRY, 2001, 382 (05) :727-733

[10] Defects in regulation of apoptosis in caspase-2-deficient mice [J].

Bergeron, L ;

Perez, GI ;

Macdonald, G ;

Shi, LF ;

Sun, Y ;

Jurisicova, A ;

Varmuza, S ;

Latham, KE ;

Flaws, JA ;

Salter, JCM ;

Hara, H ;

Moskowitz, MA ;

Li, E ;

Greenberg, A ;

Tilly, JL ;

Yuan, JY .

GENES & DEVELOPMENT, 1998, 12 (09) :1304-1314

← 1 2 3 4 5 6 7 8 9 10 →