Background There is a paucity of information on alternative, nutrition-based treatments for insulin-dependent diabetes. Primary Study Objective This case report provides detailed information on the nutrition-based treatment of a man with insulin-dependent diabetes. Methods/Design This is a single case report taken from the author's private practice. Setting The treatment was provided at a private office in New York, NY, USA. Participants A single patient in the author's practice is reported. Intervention The patient was treated with a combination of pancreatic enzymes, supplements and nutrients, and cleansing and detoxification procedures, plus amber lenses for severe insomnia. Primary Outcome Measures The outcome measures were patient self-report of symptoms, overall well-being, and function at work and in leisure time; observation of the patient by the physician; and blood work. Results The patient described dramatic, sustained improvement in terms of symptoms, function, well-being, and life satisfaction. Improvement in blood sugar control was documented by blood work. Conclusion The complex, tailored nutritional protocol combined with detoxification procedures, resulted in marked improvement in a patient who had been treated by numerous different physicians without benefit prior to his consulting with the author.