Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

被引：20

作者：

Naranmandakh, Shinen ^{[1
]}

Murata, Toshihiro ^{[2
]}

Odonbayar, Batsukh ^{[2
]}

Suganuma, Keisuke ^{[3
]}

Batkhuu, Javzan ^{[4
]}

Sasaki, Kenroh ^{[2
]}

机构：

[1] Natl Univ Mongolia, Sch Arts & Sci, Ulaanbaatar 14201, Mongolia

[2] Tohoku Med & Pharmaceut Univ, Dept Pharmacognosy, Aoba Ku, Sendai, Miyagi 9818558, Japan

[3] Obihiro Univ Agr & Vet Med, Res Ctr Global Agromed, Obihiro, Hokkaido 0808555, Japan

[4] Natl Univ Mongolia, Sch Engn & Appl Sci, Ulaanbaatar 14201, Mongolia

来源：

JOURNAL OF NATURAL MEDICINES | 2018年 / 72卷 / 02期

关键词：

Fomitopsis officinalis; Traditional medicinal mushroom; Agarikon; Lanostane triterpenoid; Trypanosoma; Mongolia; ANTITRYPANOSOMAL ACTIVITY; FRUITING BODIES; FUNGUS; ACIDS;

D O I：

10.1007/s11418-018-1182-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fomitopsis officinalis is a medicinal fungus, known as 'Agarikon', and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 2-5 and 8 exhibited moderate inhibition activities with IC50 values ranging from 7.0-27.1 A mu M.

引用

页码：523 / 529

页数：7

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