Differential brain activation in anorexia nervosa to Fat and Thin words during a Stroop task

被引：49

作者：

Redgrave, Graham W. ^{[1
]}

Bakker, Arnold ^{[3
]}

Bello, Nicholas T. ^{[1
]}

Caffo, Brian S. ^{[4
]}

Coughlin, Janelle W. ^{[1
]}

Guarda, Angela S. ^{[1
]}

McEntee, Julie E. ^{[1
]}

Pekar, James J. ^{[2
,5
]}

Reinblatt, Shauna P. ^{[1
]}

Verduzco, Guillermo ^{[1
]}

Moran, Timothy H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Psychol & Brain Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[5] FM Kirby Res Ctr Funct Brain Imaging, Kennedy Krieger Inst, Baltimore, MD USA

来源：

NEUROREPORT | 2008年 / 19卷 / 12期

关键词：

anorexia nervosa; attentional bias; dorsolateral prefrontal cortex; drive for thinness; emotional Stroop; fear of fatness; functional magnetic resonance imaging; insula; neuroimaging; psychopathology;

D O I：

10.1097/WNR.0b013e32830a70f2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured brain activation in six anorexia nervosa patients and six healthy controls performing a novel emotional Stroop task using Fat, Thin, and Neutral words, and words made of XXXXs. Reaction times increased in the patient group in Thin and Fat conditions. In the Thin-XXXX contrast, patients showed greater activation than controls at the junction of left insula, frontal and temporal lobes and in left middle and medial frontal gyri. In the Fat-XXXX contrast, controls showed greater activation in left dorsolateral prefrontal cortex and right parietal areas. Mechanisms underlying attentional bias in anorexia nervosa likely differ under conditions of positive and negative valence. This paradigm is a promising tool to examine neural mediation of emotional response in anorexia nervosa.

引用

页码：1181 / 1185

页数：5

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