A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth

被引：55
作者：
Bidwell, Gene L., III [1 ,2 ]
Perkins, Eddie [2 ,3 ,4 ]
Rancher, Drazen [1 ,2 ]
机构：
[1] Univ Mississippi, Med Ctr, Dept Biochem, Jackson, MS 39216 USA
[2] Univ Mississippi, Med Ctr, Inst Canc, Jackson, MS 39216 USA
[3] Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA
[4] Univ Mississippi, Med Ctr, Dept Neurobiol & Anat Sci, Jackson, MS 39216 USA
来源：
CANCER LETTERS | 2012年 / 319卷 / 02期
关键词：
Elastin-like polypeptide; c-Myc; Thermal targeting; Therapeutic peptide; Breast cancer; INTENSITY FOCUSED ULTRASOUND; RADIOFREQUENCY-OUTPUT POWER; ELASTIN-LIKE POLYPEPTIDE; HYPERTHERMIA TREATMENT; REGIONAL HYPERTHERMIA; CANCER; TEMPERATURE; PEPTIDES; ACCUMULATION; RADIOTHERAPY;
D O I：
10.1016/j.canlet.2011.12.042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although surgical resection with adjuvant chemotherapy and/or radiotherapy are used to treat breast tumors, normal tissue tolerance, development of metastases, and inherent tumor resistance to radiation or chemotherapy can hinder a successful outcome. We have developed a thermally responsive polypeptide, based on the sequence of Elastin-like polypeptide (ELP), that inhibits breast cancer cell proliferation by blocking the activity of the oncogenic protein c-Myc. Following systemic administration, the ELP - delivered c-Myc inhibitory peptide was targeted to tumors using focused hyperthermia, and significantly reduced tumor growth in an orthotopic mouse model of breast cancer. This work provides a new modality for targeted delivery of a specific oncogene inhibitory peptide, and this strategy may be expanded for delivery of other therapeutic peptides or small molecule drugs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：136 / 143
页数：8
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