A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth

被引：55

作者：

Bidwell, Gene L., III ^{[1
,2
]}

Perkins, Eddie ^{[2
,3
,4
]}

Rancher, Drazen ^{[1
,2
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Biochem, Jackson, MS 39216 USA

[2] Univ Mississippi, Med Ctr, Inst Canc, Jackson, MS 39216 USA

[3] Univ Mississippi, Med Ctr, Dept Neurosurg, Jackson, MS 39216 USA

[4] Univ Mississippi, Med Ctr, Dept Neurobiol & Anat Sci, Jackson, MS 39216 USA

来源：

CANCER LETTERS | 2012年 / 319卷 / 02期

关键词：

Elastin-like polypeptide; c-Myc; Thermal targeting; Therapeutic peptide; Breast cancer; INTENSITY FOCUSED ULTRASOUND; RADIOFREQUENCY-OUTPUT POWER; ELASTIN-LIKE POLYPEPTIDE; HYPERTHERMIA TREATMENT; REGIONAL HYPERTHERMIA; CANCER; TEMPERATURE; PEPTIDES; ACCUMULATION; RADIOTHERAPY;

D O I：

10.1016/j.canlet.2011.12.042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although surgical resection with adjuvant chemotherapy and/or radiotherapy are used to treat breast tumors, normal tissue tolerance, development of metastases, and inherent tumor resistance to radiation or chemotherapy can hinder a successful outcome. We have developed a thermally responsive polypeptide, based on the sequence of Elastin-like polypeptide (ELP), that inhibits breast cancer cell proliferation by blocking the activity of the oncogenic protein c-Myc. Following systemic administration, the ELP - delivered c-Myc inhibitory peptide was targeted to tumors using focused hyperthermia, and significantly reduced tumor growth in an orthotopic mouse model of breast cancer. This work provides a new modality for targeted delivery of a specific oncogene inhibitory peptide, and this strategy may be expanded for delivery of other therapeutic peptides or small molecule drugs. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：136 / 143

页数：8

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