Mistletoe in oncological treatment: a systematic review Part 1: survival and safety

被引：51

作者：

Freuding, M. ^{[1
]}

Keinki, C. ^{[1
]}

Micke, O. ^{[2
]}

Buentzel, J. ^{[3
]}

Huebner, Jutta ^{[1
]}

机构：

[1] Univ Klinikum Jena, Klin Innere Med Hamatol & Internist Onkol 2, Klinikum 1, D-07747 Jena, Germany

[2] Franziskus Hosp, Klin Strahlentherapie & Radioonkol, Kiskerstr 26, D-33615 Bielefeld, Germany

[3] Sudharzklinikum Nordhausen, Klin Hals Nasen Ohren Heilkunde, Dr Robert Koch Str 39, D-99734 Nordhausen, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2019年 / 145卷 / 03期

关键词：

Mistletoe; Cancer; Complementary and alternative medicine (CAM); Patient-relevant outcomes; PROSPECTIVE CONTROLLED COHORT; LONG-TERM THERAPY; QUALITY-OF-LIFE; BREAST-CANCER PATIENTS; VISCUM-ALBUM L; COMPARING ADDITIONAL TREATMENT; GALACTOSIDE-SPECIFIC LECTIN; MATCHED-PAIR DESIGN; ALTERNATIVE MEDICINE; COMPLEMENTARY TREATMENT;

D O I：

10.1007/s00432-018-02837-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Mistletoe treatment of cancer patients is discussed highly controversial in the scientific literature. Aim of this systematic review is to give an extensive overview about current state of research concerning mistletoe therapy of oncologic patients regarding survival, quality of life and safety. Methods In September and October 2017 Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and "Science Citation Index Expanded" (Web of Science) were systematically searched. Results The search strategy identified 3647 hits and 28 publications with 2639 patients were finally included in this review. Mistletoe was used in bladder cancer, breast cancer, other gynecological cancers (cervical cancer, corpus uteri cancer, and ovarian cancer), colorectal cancer, other gastrointestinal cancer (gastric cancer and pancreatic cancer), glioma, head and neck cancer, lung cancer, melanoma and osteosarcoma. In nearly all studies, mistletoe was added to a conventional therapy. Patient relevant endpoints were overall survival (14 studies, n = 1054), progression- or disease-free survival or tumor response (10 studies, n = 1091). Most studies did not show any effect of mistletoe on survival. Especially high quality studies do not show any benefit. Conclusions With respect to survival, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer.

引用

页码：695 / 707

页数：13

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