Gd-complexes of DTPA-bis(amides) functionalized by pyridine and picolinamide: Synthesis, thermodynamic stability, and relaxivity properties

被引：0

作者：

Sk, Nasiruzzaman ^{[3
]}

Park, Md. Ji-Ae ^{[1
,2
]}

Chang, Yongmin ^{[1
,2
]}

Kim, Tae-Jeong ^{[3
]}

机构：

[1] Kyungpook Natl Univ, Dept Diagnost Radiol, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Dept Mol Med, Taegu 702701, South Korea

[3] Kyungpook Natl Univ, Dept Appl Chem, Taegu 702701, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2008年 / 29卷 / 06期

关键词：

MRI CA; Gd(DTPA-bisamide); pyridine; picolinamide; T1; relaxivity;

D O I：

10.5012/bkcs.2008.29.6.1211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of DTPA-bis(amides) functionalized by pyridine (la-c) and N-phenylpicolinamide) (Id-e) and their Gd(III)-complexes of the type [Gd(1)(H2O)]center dot xH(2)O (2a-e) were prepared and characterized by analytical and spectroscopic techniques. Potentiality of 2a-a as contrast agents for magnetic resonance imaging (MRI CA) was investigated by measuring relevant physicochemical properties and relaxivities and compared with [Gd(DTPA-BMA)(H2O)] (DTPA-BMA=N,N ''-di(methylcarbamoylmethyl)diethylenetriamine-N,N',N ''-triacetate) (Omniscan). The R, relaxivities of aqueous solutions of 2a-c are in the range of 3.33-5.02 nM(-1)sec(-1), which are comparable with those of Omniscan (R) (r(1) =4.58 mM(-1)sec(-1)). Complexes 2d-e, insoluble in water, exhibit relatively higher R, values (8.1-8.3 mM(-1)sec(-1)) in HP-beta-CD solutions.

引用

页码：1211 / 1216

页数：6

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