The synthesis of pennogenin 3-O-β-D-glucopyranosyl-(1 → 3)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside

被引：6

作者：

Luo, Xin-Feng ^{[1
]}

Lei, Fan ^{[1
]}

He, Yi ^{[1
]}

Pei, Shu-Chen ^{[1
]}

Hai, Li ^{[1
]}

Qian, Shan ^{[2
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Chengdu 610041, Peoples R China

[2] Xihua Univ, Bioengn Coll, Chengdu 610039, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 04期

关键词：

pennogenin; alpha-L-rhamnopyranoside; beta-D-glucopyranoside; antitumor activity; synthesis; GRACILLIN; SAPONINS; GLYCOSYL;

D O I：

10.1080/10286020.2011.653348

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Pennogenin 3-O-beta-D-glucopyranosyl-(1 -> 3)-[alpha-L-rhamnopyranosyl-(1 -> 2)]-beta-D-glucopyranoside, a monodesmosidic saponin isolated from Paris polyphylla Smith var. yunnanensis with promised antitumor activities, was firstly synthesized from glucoside thiol via nine steps and with 27% overall yield.

引用

页码：314 / 321

页数：8

共 27 条

[21]

Tim E.A., 2009, J AM CHEM SOC, V131, P1607

[22]

YOSHIHIRO M, 2001, BIOL PHARM BULL, V24, P1286

[23] Carbohydrate chemistry in the total synthesis of Saponins [J].

Yu, Biao ;

Zhang, Yichun ;

Tang, Pingping .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2007, 2007 (31) :5145-5161

[24] Current Synthesis of Triterpene Saponins [J].

Yu, Biao ;

Sun, Jiansong .

CHEMISTRY-AN ASIAN JOURNAL, 2009, 4 (05) :642-654

[25] Saponins from the Processed Rhizomes of Polygonatum kingianum [J].

Yu, He-Shui ;

Ma, Bai-Ping ;

Kang, Li-Ping ;

Zhang, Tao ;

Jiang, Feng-Juan ;

Zhang, Jie ;

Zou, Peng ;

Zhao, Yang ;

Xiong, Cheng-Qi ;

Tan, Da-Wei ;

Song, Xin-bo ;

Yu, Kate .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (09) :1011-1014

[26] Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry [J].

Zhang, Ting ;

Liu, Hai ;

Liu, Xue-Ting ;

Xu, De-ran ;

Chen, Xiao-qing ;

Wang, Qiang .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2010, 51 (01) :114-124

[27] The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides [J].

Zou, CC ;

Hou, SJ ;

Shi, Y ;

Lei, PS ;

Liang, XT .

CARBOHYDRATE RESEARCH, 2003, 338 (08) :721-727

← 1 2 3 →