Palladium-Catalyzed Sequential Formation of C-C Bonds: Efficient Assembly of 2-Substituted and 2,3-Disubstituted Quinolines

被引：100
作者：
Ji, Xiaochen [1 ]
Huang, Huawen [1 ]
Li, Yibiao [1 ]
Chen, Huoji [1 ]
Jiang, Huanfeng [1 ]
机构：
[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 29期
基金：
中国国家自然科学基金;
关键词：
C?C bond formation; oxidation; palladium; quinolines; 3-COMPONENT POVAROV REACTION; ARENE CARBOXYLIC-ACIDS; SUBSTITUTED QUINOLINES; DECARBOXYLATIVE OLEFINATION; HETEROAROMATIC-COMPOUNDS; BIOLOGICAL EVALUATION; ANTIBACTERIAL AGENTS; MOLECULAR-OXYGEN; DIRECT ARYLATION; AROMATIC-AMINES;
D O I：
10.1002/anie.201202412
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7292 / 7296
页数：5
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