Synthesis of a nitrogen analogue of salacinol and its α-glucosidase inhibitory activity

被引：42
|
作者：
Muraoka, O
Ying, S
Yoshikai, K
Matsuura, Y
Yamada, E
Minematsu, T
Tanabe, G
Matsuda, H
Yoshikawa, M
机构：
[1] Kinki Univ, Sch Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan
[2] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 11期
关键词：
cyclic sulfate; erythritol; salacinol; glycosidase inhibitor; glucosidase inhibitor; azasugar;
D O I：
10.1248/cpb.49.1503
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A nitrogen analogue 4 of the naturally occurring sulfonium ion salacinol (1), a potent alpha -glucosidase inhibitor isolated from the Ayruvedic medicine Salacia reticulata, was synthesized and its inhibitory activity against alpha -glucosidase tested. Substitution of the sulfur atom in I with a nitrogen reduced the activity considerably. The solid-state stereostructure of the related compound (5) was determined on the basis of single crystal X-ray measurement.
引用
收藏
页码：1503 / 1505
页数：3
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