A Tumor-Microenvironment-Responsive Lanthanide-Cyanine FRET Sensor for NIR-II Luminescence-Lifetime In Situ Imaging of Hepatocellular Carcinoma

被引：194

作者：

Zhao, Mengyao ^{[1
,2
]}

Li, Benhao ^{[1
,2
]}

Wu, Yifan ^{[1
,2
]}

He, Haisheng ^{[1
,2
]}

Zhu, Xinyan ^{[1
,2
]}

Zhang, Hongxin ^{[1
,2
]}

Dou, Chaoran ^{[3
]}

Feng, Lishuai ^{[3
]}

Fan, Yong ^{[1
,2
]}

Zhang, Fan ^{[1
,2
]}

机构：

[1] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200433, Peoples R China

[2] Fudan Univ, iChem, Shanghai 200433, Peoples R China

[3] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai, Peoples R China

来源：

ADVANCED MATERIALS | 2020年 / 32卷 / 28期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

energy transfer; hepatocellular carcinoma detection; lanthanides; NIR-II dyes; NIR-II lifetime imaging; NANOPARTICLES; NANOCRYSTALS;

D O I：

10.1002/adma.202001172

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Deep tissue imaging in the second near-infrared (NIR-II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to tissue absorption and scattering hampers its application for accurate in vivo biosensing. Here, lifetime-based in situ hepatocellular carcinoma (HCC) detection in NIR-II region is presented using a tumor-microenvironment (peroxynitrite, ONOO-)-responsive lanthanide-cyanine Forster resonance energy transfer (FRET) nanosensor. A specially designed ONOO--responsive NIR-II dye, MY-1057, is synthesized as the FRET acceptor. Robust lifetime sensing is demonstrated to be independent of tissue penetration depth. Tumor lesions are accurately distinguished from normal tissue due to the recovery lifetime. Magnetic resonance imaging and liver dissection results illustrate the reliability of lifetime-based detection in single and multiple HCC models. Moreover, the ONOO- amount can be calculated according to the standard curve.

引用

页数：7

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