HPLC of structural isomers with cyclodextrin-poly(vinylamine)-coated silica columns .1. Synthesis and characterization of cyclodextrin-bonded stationary phases by NMR solid state

Different supports for high-performance liquid chromatography are prepared by using the coating technology. These supports are based on silica beads coated with a β-cyclodextrin-containing poly(vinylamine). Surface area, pore size distribution, and solidstate nuclear magnetic resonance are used for the characterization of these supports. The two different methods of preparation used lead to different arrangements of the polymer layers; hence, the supports have different mobility, rigidity, and accessibility of the cyclodextrin ring.