Detection of methamphetamine/amphetamine in human urine based on surface-enhanced Raman spectroscopy and acidulation treatments

被引：63

作者：

Nuntawong, Noppadon ^{[1
]}

Eiamchai, Pitak ^{[1
]}

Somrang, Witchaphol ^{[2
]}

Denchitcharoen, Somyod ^{[2
]}

Limwichean, Saksorn ^{[1
]}

Horprathum, Mati ^{[1
]}

Patthanasettakul, Viyapol ^{[1
]}

Chaiya, Sanit ^{[3
]}

Leelapojanaporn, Ampika ^{[3
]}

Saiseng, Somjet ^{[4
]}

Pongsethasant, Predee ^{[5
]}

Chindaudom, Pongpan ^{[1
]}

机构：

[1] Natl Elect & Comp Technol Ctr, 112 Thailand Sci Pk, Pathum Thani, Thailand

[2] King Mongkuts Univ Technol Thonburi, Fac Sci, Bangkok, Thailand

[3] Cent Inst Forens Sci, Bangkok, Thailand

[4] Police Forens Sci Ctr 1, Pathum Thani, Thailand

[5] Police Forens Sci Ctr 10, Yala, Thailand

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 239卷

关键词：

Raman; SERS; Trace detection; Methamphetamine; Amphetamine; Nitric acid; Human urine; Silver nanorods; SILVER; SERS; NANOPARTICLES;

D O I：

10.1016/j.snb.2016.07.129

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Based on the Raman spectrocopy of the nanostructure-based SERS chips, the trace amount of methamphetamine and its primary metabolite, i.e., amphetamine, were successfully identified from human urine. The SERS substrates were self-assembled vertically-aligned silver nanorods prepared by the magnetron sputtering technique. The matrix spikes of the human urine specimens were prepared to simulate those of the methamphetamine abusers. With the acidulation treatments to the specimen samples, the organic urea-based byproducts were clearly separated. The remaining dissolved metham-phetamine/amphetamine in the urine specimens could therefore be enhanced for the SERS analyses, without any interference from the urea. The performance of the proposed acidulation treatments toward the SERS detections of the matrix-spike human urine specimens yielded the detection limit at 50 ng/mL. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：139 / 146

页数：8

共 19 条

[11] Surface-enhanced Raman scattering substrate of silver nanoparticles depositing on AAO template fabricated by magnetron sputtering [J].

Nuntawong, Noppadon ;

Horprathum, Mati ;

Eiamchai, Pitak ;

Wong-ek, Krongkamol ;

Patthanasettakul, Viyapol ;

Chindaudom, Pongpan .

VACUUM, 2010, 84 (12) :1415-1418

[12]

Panomnoptham S., 2009, THESIS

[13] Development and validation of a presumptive colour spot test method for the detection of piperazine analogues in seized illicit materials [J].

Philp, Morgan ;

Shimmon, Ronald ;

Stojanovska, Natasha ;

Tahtouh, Mark ;

Fu, Shanlin .

ANALYTICAL METHODS, 2013, 5 (20) :5402-5410

[14] A novel fluorescence nanosensor based on 1,8-naphthalimide-thiophene doped silica nanoparticles, and its application to the determination of methamphetamine [J].

Rouhani, Shohre ;

Haghgoo, Soheila .

SENSORS AND ACTUATORS B-CHEMICAL, 2015, 209 :957-965

[15] Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers [J].

Schepers, RJF ;

Oyler, JM ;

Joseph, RE ;

Cone, EJ ;

Moolchan, ET ;

Huestis, MA .

CLINICAL CHEMISTRY, 2003, 49 (01) :121-132

[16] Sensing of survivin mRNA in malignant astrocytes using graphene oxide nanocarrier-supported oligonucleotide molecular beacons [J].

Stobiecka, Magdalena ;

Dworakowska, Beata ;

Jakiela, Slawomir ;

Lukasiak, Agnieszka ;

Chalupa, Agata ;

Zembrzycki, Krzysztof .

SENSORS AND ACTUATORS B-CHEMICAL, 2016, 235 :136-145

[17]

Triplett J.S., 2015, RAMAN SPECTROSCOPY M

[18] False positives and false negatives with a cocaine-specific field test and modification of test protocol to reduce false decision [J].

Tsumura, Y ;

Mitome, T ;

Kimoto, S .

FORENSIC SCIENCE INTERNATIONAL, 2005, 155 (2-3) :158-164

[19]

United Nation, 2006, REC METH ID AN AMPH

← 1 2 →