Sustained stomach specific delivery of piroxicam from floating emulsion polyelectrolyte complex beads

被引：0

作者：

Verma, Anurag ^{[1
]}

Dixit, Raghav ^{[1
]}

Pandit, Jayant K. ^{[2
]}

机构：

[1] IFTM Univ, Sch Pharmaceut Sci, Moradabad 244001, India

[2] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH | 2012年 / 71卷 / 06期

关键词：

Chitosan; Emulsion PEC beads; Floating drug delivery; Gelucire; Piroxicam; ALGINATE GEL BEADS; DRUG-DELIVERY; FORMULATION; RELEASE;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study presents development of floating emulsion polyelectrolyte complex (PEC) beads based on gellan-chitosan PEC and Gelucire 39/01 and 50/13 without using any chemical crosslinker, and release from developed beads of piroxicam (PRM) in 0.1 M HCl(pH 1.2). Developed beads showed excellent buoyancy, significantly improved encapsulation efficiency and sustained release of PRM compared to floating gellan-chitosan beads bearing PRM. Thus emulsion PEC beads may form a potential stomach site specific drug delivery system for PRM delivery.

引用

页码：407 / 412

页数：6

共 17 条

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