Intracellular signalling - Key enzyme in leptin-induced anorexia

被引：471

作者：

Niswender, KD ^{[1
]}

Morton, GJ

Stearns, WH

Rhodes, CJ

Myers, MG

Schwartz, MW

机构：

[1] Univ Washington, Sch Med, Div Metab Endocrinol & Nutr, Seattle, WA 98104 USA

[2] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA

[3] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

[4] Pacific NW Res Inst, Seattle, WA 98122 USA

来源：

NATURE | 2001年 / 413卷 / 6858期

关键词：

D O I：

10.1038/35101657

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：794 / 795

页数：2

共 12 条

[1]

Cone RD, 1996, RECENT PROG HORM RES, V51, P287

[2] Specificity and mechanism of action of some commonly used protein kinase inhibitors [J].

Davies, SP ;

Reddy, H ;

Caivano, M ;

Cohen, P .

BIOCHEMICAL JOURNAL, 2000, 351 (351) :95-105

[3] Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity [J].

El-Haschimi, K ;

Pierroz, DD ;

Hileman, SM ;

Bjorbæk, C ;

Flier, JS .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) :1827-1832

[4] Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line [J].

Harvey, J ;

McKay, NG ;

Walker, KS ;

Van der Kaay, J ;

Downes, CP ;

Ashford, MLJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) :4660-4669

[5] Recombinant leptin for weight loss in obese and lean adults - A randomized, controlled, dose-escalation trial [J].

Heymsfield, SB ;

Greenberg, AS ;

Fujioka, K ;

Dixon, RM ;

Kushner, R ;

Hunt, T ;

Lubina, JA ;

Patane, J ;

Self, B ;

Hunt, P ;

McCamish, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1568-1575

[6] Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression [J].

McMinn, JE ;

Wilkinson, CW ;

Havel, PJ ;

Woods, SC ;

Schwartz, MW .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (02) :R695-R703

[7] IRS-1 ACTIVATES PHOSPHATIDYLINOSITOL 3'-KINASE BY ASSOCIATING WITH SRC HOMOLOGY-2 DOMAINS OF P85 [J].

MYERS, MG ;

BACKER, JM ;

SUN, XJ ;

SHOELSON, S ;

HU, P ;

SCHLESSINGER, J ;

YOAKIM, M ;

SCHAFFHAUSEN, B ;

WHITE, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10350-10354

[8] Cellular mechanisms of insulin resistance [J].

Shulman, GI .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (02) :171-176

[9] Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats [J].

Spanswick, D ;

Smith, MA ;

Mirshamsi, S ;

Routh, VH ;

Ashford, MLJ .

NATURE NEUROSCIENCE, 2000, 3 (08) :757-758

[10] Leptin activation of Stat3 in the hypothalamus of wildtype and ob/ob mice but not db/db mice [J].

Vaisse, C ;

Halaas, JL ;

Horvath, CM ;

Darnell, JE ;

Stoffel, M ;

Friedman, JM .

NATURE GENETICS, 1996, 14 (01) :95-97

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