Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada

被引：10

作者：

Chaudhry, Ahsan ^{[1
,2
]}

Bastien, Nathalie ^{[3
]}

Li, Yan ^{[3
]}

Scott, Allison ^{[4
]}

Pabbaraju, Kanti ^{[5
]}

Stewart, Douglas ^{[1
,2
]}

Wong, Sallene ^{[5
]}

Drews, Steven J. ^{[6
,7
]}

机构：

[1] Univ Calgary, Dept Oncol, Calgary, AB, Canada

[2] Univ Calgary, Dept Med, Calgary, AB, Canada

[3] Natl Microbiol Lab, Winnipeg, MB, Canada

[4] Surveillance & Assessment Accountabil & Performan, Edmonton, AB, Canada

[5] ProvLab Alberta Calgary, Calgary, AB, Canada

[6] ProvLab Alberta Edmonton, Edmonton, AB, Canada

[7] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2016年 / 10卷 / 06期

关键词：

H3N2; influenza; neuraminidase inhibitors; reduced susceptibility; resistance; sequence analysis; NEURAMINIDASE INHIBITORS; SUSCEPTIBILITY; ASSAYS;

D O I：

10.1111/irv.12415

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This manuscript describes the identification of an oseltamivir-resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada, during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir-resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient.

引用

页码：532 / 535

页数：4

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