Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada

被引：10
|
作者：
Chaudhry, Ahsan [1 ,2 ]
Bastien, Nathalie [3 ]
Li, Yan [3 ]
Scott, Allison [4 ]
Pabbaraju, Kanti [5 ]
Stewart, Douglas [1 ,2 ]
Wong, Sallene [5 ]
Drews, Steven J. [6 ,7 ]
机构：
[1] Univ Calgary, Dept Oncol, Calgary, AB, Canada
[2] Univ Calgary, Dept Med, Calgary, AB, Canada
[3] Natl Microbiol Lab, Winnipeg, MB, Canada
[4] Surveillance & Assessment Accountabil & Performan, Edmonton, AB, Canada
[5] ProvLab Alberta Calgary, Calgary, AB, Canada
[6] ProvLab Alberta Edmonton, Edmonton, AB, Canada
[7] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada
来源：
INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2016年 / 10卷 / 06期
关键词：
H3N2; influenza; neuraminidase inhibitors; reduced susceptibility; resistance; sequence analysis; NEURAMINIDASE INHIBITORS; SUSCEPTIBILITY; ASSAYS;
D O I：
10.1111/irv.12415
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This manuscript describes the identification of an oseltamivir-resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada, during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir-resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient.
引用
收藏
页码：532 / 535
页数：4
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