Cascade Reactions to Substituted 1 H -Pyrrole-3-carbonitriles via Ligand-Free Palladium(II)-Catalyzed C(sp)-C(sp 2 ) Coupling

被引：8
作者：
Wang, Zijuan [1 ]
Chen, Wenteng [1 ]
Luo, Haofan [1 ]
He, Chang [1 ]
Zhang, Guolin [1 ]
Yu, Yongping [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2020年 / 52卷 / 11期
基金：
中国国家自然科学基金;
关键词：
C-C coupling; palladium; ligand-free; cascade reactions; substituted; 1; H; -pyrrole-3-carbonitriles; INHIBITORS; DERIVATIVES; VONOPRAZAN; EFFICIENT; COPPER;
D O I：
10.1055/s-0039-1691731
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and simple synthesis of substituted 1 H -pyrrole-3-carbonitriles was developed. This reaction is a palladium(II)-catalyzed cascade of C(sp)-C(sp (2) ) coupling followed by intramolecular C-N bond formation. The method can tolerate various substrates with satisfactory yields. Its ligand-free conditions and high efficiency make this method particularly attractive.
引用
收藏
页码：1659 / 1665
页数：7
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