8-Hydroxy-2′-deoxyguanosine expression predicts hepatocellular carcinoma outcome

被引：18

作者：

Li, Shengmian ^{[1
]}

Wang, Xiaoling ^{[2
]}

Wui, Yijuan ^{[1
]}

Zhang, Huijing ^{[1
]}

Zhang, Lan ^{[1
]}

Wang, Cuiju ^{[3
]}

Zhang, Ruixing ^{[1
]}

Guo, Zhanjun ^{[1
,4
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Pathol, Shijiazhuang 050011, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 4, Dept Gynecol Ultrasound, Shijiazhuang 050011, Hebei, Peoples R China

[4] Hebei Med Univ, Hebei Key Lab Lab Anim Sci, Shijiazhuang 050011, Hebei, Peoples R China

来源：

ONCOLOGY LETTERS | 2012年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

8-OHdG; hepatocellular carcinoma; outcome; survival; OXIDATIVE DNA-DAMAGE; CHRONIC HEPATITIS-C; RENAL-CELL CARCINOMA; URINARY; 8-HYDROXY-2-DEOXYGUANOSINE; POSTOPERATIVE RECURRENCE; PROGNOSTIC-SIGNIFICANCE; VIRUS-INFECTION; STRESS; CARCINOGENESIS; MARKER;

D O I：

10.3892/ol.2011.477

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.

引用

页码：338 / 342

页数：5

共 29 条

[21] PREDICTIVE FACTORS FOR POSTOPERATIVE RECURRENCE OF HEPATOCELLULAR-CARCINOMA [J].

OKADA, S ;

SHIMADA, K ;

YAMAMOTO, J ;

TAKAYAMA, T ;

KOSUGE, T ;

YAMASAKI, S ;

SAKAMOTO, M ;

HIROHASHI, S .

GASTROENTEROLOGY, 1994, 106 (06) :1618-1624

[22] Oxidative damage and fibrogenesis [J].

Poli, G ;

Parola, M .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (1-2) :287-305

[23] Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma [J].

Poon, RTP ;

Fan, ST ;

Wong, J .

ANNALS OF SURGERY, 2000, 232 (01) :10-24

[24] Oxidative stress during viral infection: A review [J].

Schwarz, KB .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 21 (05) :641-649

[25] URINARY 8-HYDROXY-2'-DEOXYGUANOSINE AS A BIOLOGICAL MARKER OF INVIVO OXIDATIVE DNA DAMAGE [J].

SHIGENAGA, MK ;

GIMENO, CJ ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (24) :9697-9701

[26] Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection [J].

Sumida, Y ;

Nakashima, T ;

Yoh, T ;

Nakajima, Y ;

Ishikawa, H ;

Mitsuyoshi, H ;

Sakamoto, Y ;

Okanoue, T ;

Kashima, K ;

Nakamura, H ;

Yodoi, J .

JOURNAL OF HEPATOLOGY, 2000, 33 (04) :616-622

[27] Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C [J].

Tanaka, H. ;

Fujita, N. ;

Sugimoto, R. ;

Urawa, N. ;

Horiike, S. ;

Kobayashi, Y. ;

Iwasa, M. ;

Ma, N. ;

Kawanishi, S. ;

Watanabe, S. ;

Kaito, M. ;

Takei, Y. .

BRITISH JOURNAL OF CANCER, 2008, 98 (03) :580-586

[28] Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress [J].

Tanaka, T ;

Kondo, S ;

Iwasa, Y ;

Hiai, H ;

Toyokuni, S .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (06) :2149-2157

[29] Regulatory mechanisms of viral hepatitis B and C [J].

Waris, G ;

Siddiqui, A .

JOURNAL OF BIOSCIENCES, 2003, 28 (03) :311-321

← 1 2 3 →