8-Hydroxy-2′-deoxyguanosine expression predicts hepatocellular carcinoma outcome

被引：18

作者：

Li, Shengmian ^{[1
]}

Wang, Xiaoling ^{[2
]}

Wui, Yijuan ^{[1
]}

Zhang, Huijing ^{[1
]}

Zhang, Lan ^{[1
]}

Wang, Cuiju ^{[3
]}

Zhang, Ruixing ^{[1
]}

Guo, Zhanjun ^{[1
,4
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Hebei, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Pathol, Shijiazhuang 050011, Hebei, Peoples R China

[3] Hebei Med Univ, Hosp 4, Dept Gynecol Ultrasound, Shijiazhuang 050011, Hebei, Peoples R China

[4] Hebei Med Univ, Hebei Key Lab Lab Anim Sci, Shijiazhuang 050011, Hebei, Peoples R China

来源：

ONCOLOGY LETTERS | 2012年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

8-OHdG; hepatocellular carcinoma; outcome; survival; OXIDATIVE DNA-DAMAGE; CHRONIC HEPATITIS-C; RENAL-CELL CARCINOMA; URINARY; 8-HYDROXY-2-DEOXYGUANOSINE; POSTOPERATIVE RECURRENCE; PROGNOSTIC-SIGNIFICANCE; VIRUS-INFECTION; STRESS; CARCINOGENESIS; MARKER;

D O I：

10.3892/ol.2011.477

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is characterized by increased oxidative stress and the production of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is one of the main mutagenic modifications of DNA by oxidative stress. We analyzed the association of 8-OHdG with post-operative survival and revealed that low levels of 8-OHdG are associated with significantly shorter survival time. Moreover, levels of 8-OHdG were associated with HCC characteristics, including tumor size, tumor quantity, clinical staging, Child classification, portal vein thrombosis and ascites. These results suggest that oxidative damage is a useful prognostic marker in HCC when other clinical characteristics are present with 8-OHdG.

引用

页码：338 / 342

页数：5

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