Enhanced bone regeneration of zirconia-toughened alumina nanocomposites using PA6/HA nanofiber coating via electrospinning

被引：9
作者：
Esfahani, Hamid [1 ]
Darvishghanbar, Mahsa [1 ]
Farshid, Behzad [2 ]
机构：
[1] Bu Ali Sina Univ, Dept Mat Engn, Hamadan 6517838695, Iran
[2] SUNY Stony Brook, Mat Sci & Chem Engn Dept, Stony Brook, NY 11794 USA
来源：
JOURNAL OF MATERIALS RESEARCH | 2018年 / 33卷 / 24期
关键词：
bone; fiber; nanostructure; ZINC-DOPED HYDROXYAPATITE; SOL-GEL SYNTHESIS; COMPOSITE NANOPOWDERS; NANO-HYDROXYAPATITE; TISSUE; BIOMATERIALS; CERAMICS; GROWTH;
D O I：
10.1557/jmr.2018.391
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study, the bioactivity and cytocompatibility of electrospun polyamide 6 (PA6)/hydroxyapatite (HA) coating on zirconia-toughened alumina (ZTA) were investigated. Adjusting the PA6/HA ratio to 1.15 (w/w) had a significant role in achieving an appropriate fibrous coating with an average diameter of 120 +/- 10 nm and surface porosity of 64.3%. The surface of bare and coated samples was hydrophilic, which promoted bone regeneration. The adhesion test of the PA6/HA mat demonstrated that a cohesive coating was formed on the ZTA via electrospinning. The in vitro bioactivity test of the PA6/HA coating in simulated body fluid (SBF) corroborated the formation of a nanostructured bonelike apatite phase. Cytocompatibility of the samples was evaluated through in vitro osteosarcoma-like cell (MG63) culture assays. The cytotoxicity study showed that the electrospun PA6/HA coating significantly improved cell attachment and spreading. The development of such bioactive, biomedical coatings opens new avenues for bone tissue engineering applications.
引用
收藏
页码：4287 / 4295
页数：9
相关论文
共 51 条
[1]   Biocompatibility properties of polyamide 6/PCL blends composite textile scaffold using EA.hy926 human endothelial cells [J].
Abdal-hay, Abdalla ;
Khalil, Khalil Abdelrazek ;
Al-Jassir, Fawzi F. ;
Gamal-Eldeen, Amira M. .
BIOMEDICAL MATERIALS, 2017, 12 (03)
[2]   Adhesion testing of composites based on Bis-GMA/TEGDMA monomers reinforced with alumina based fillers on brass substrate [J].
Algellai, Ahmed A. ;
Tomic, Natasa ;
Vuksanovic, Marija M. ;
Dojcinovic, Marina ;
Volkov-Husovic, Tatjana ;
Radojevic, Vesna ;
Heinemann, Radmila Jancic .
COMPOSITES PART B-ENGINEERING, 2018, 140 :164-173
[3]   Bioactive and Biodegradable Nanocomposites and Hybrid Biomaterials for Bone Regeneration [J].
Allo, Bedilu A. ;
Costa, Daniel O. ;
Dixon, S. Jeffrey ;
Mequanint, Kibret ;
Rizkalla, Amin S. .
JOURNAL OF FUNCTIONAL BIOMATERIALS, 2012, 3 (02)
[4]   Preparation and characterization of wollastonite/titanium oxide nanofiber bioceramic composite as a future implant material [J].
Aly, Ibrahim H. M. ;
Mohammed, L. Abed Alrahim ;
Al-Meer, Saeed ;
Elsaid, Khalid ;
Barakat, Nasser A. M. .
CERAMICS INTERNATIONAL, 2016, 42 (10) :11525-11534
[5]  
[Anonymous], 264432008 ISO
[6]  
[Anonymous], 2013, THESIS
[7]   The nanoporous anodic alumina oxide formed by two-step anodization [J].
Ates, Sevgi ;
Baran, Evrim ;
Yazici, Birgul .
THIN SOLID FILMS, 2018, 648 :94-102
[8]   Toughness determination of zirconia toughened alumina ceramics from growth of indentation-induced cracks [J].
Basu, D ;
Sarkar, BK .
JOURNAL OF MATERIALS RESEARCH, 1996, 11 (12) :3057-3063
[9]   MG63 osteoblast cell response on Zn doped hydroxyapatite (HAp) with various surface features [J].
Begam, Howa ;
Kundu, Biswanath ;
Chanda, Abhijit ;
Nandi, Samit Kumar .
CERAMICS INTERNATIONAL, 2017, 43 (04) :3752-3760
[10]   Novel route for rapid sol-gel synthesis of hydroxyapatite, avoiding ageing and using fast drying with a 50-fold to 200-fold reduction in process time [J].
Ben-Arfa, Basam A. E. ;
Miranda Salvado, Isabel M. ;
Ferreira, Jose M. F. ;
Pullar, Robert C. .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 70 :796-804
123456