Comparison of induction chemotherapy before radiotherapy with radiotherapy only in patients with locally advanced squamous cell carcinoma of the lung

被引:33
作者
Brodin, O
Nou, E
Mercke, C
Linden, CJ
Lundstrom, R
Arwidi, A
Brink, J
Ringborg, U
机构
[1] UNIV UPPSALA HOSP,DEPT ONCOL,S-75185 UPPSALA,SWEDEN
[2] UNIV UPPSALA HOSP,DEPT LUNG MED,S-75185 UPPSALA,SWEDEN
[3] UNIV UPPSALA HOSP,REG ONCOL CTR,S-75185 UPPSALA,SWEDEN
[4] SAHLGRENS UNIV HOSP,DEPT ONCOL,GOTHENBURG,SWEDEN
[5] MALMO GEN HOSP,S-21401 MALMO,SWEDEN
[6] KAROLINSKA HOSP,RADIUMHEMMET,S-10401 STOCKHOLM,SWEDEN
关键词
squamous cell carcinoma of the lung; chemotherapy; radiotherapy; survival; local control;
D O I
10.1016/0959-8049(96)00212-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this randomised trial was to investigate the effect of induction chemotherapy before radiotherapy on survival in 302 patients with non-resectable squamous cell carcinoma of the lung. Radiotherapy, 56 Gy to the chest, was given to 154 patients and combined treatment, with chemotherapy preceding the radiotherapy, to 148 patients. Chemotherapy consisted of three courses of cisplatin (120 mg/m(2)) and etoposide (100 mg/m(2) i.v. for 3 days) administered every fourth week. Median survival was 10.5 months in the radiotherapy arm and 11 months in the combined treatment arm. The 2-year survival rate was 17% in the radiotherapy arm and 21% in the combined treatment arm. Addition of chemotherapy seemed to significantly improve survival, according to the Cox multivariate analysis (P=0.04), but as only a trend according to life-table analysis (P=0.11). Chemotherapy also accomplished a trend towards improved local control (P=0.08) and towards decreased metastatic disease (P=0.10). 2 patients in the combined treatment arm, but none in the radiotherapy arm, died from toxicity. The conclusion was that the value of the chemotherapy used in this study was very modest, but the results strongly support further research for more efficient drugs and combinations. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:1893 / 1900
页数:8
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