The role of neutrophils in equine laminitis

被引：19

作者：

Leise, Britta ^{[1
]}

机构：

[1] Louisiana State Univ, Sch Vet Med, Dept Vet Clin Sci, Baton Rouge, LA 70803 USA

来源：

CELL AND TISSUE RESEARCH | 2018年 / 371卷 / 03期

关键词：

Neutrophil; Leukocytes; Laminitis; Horse; Sepsis; BLACK-WALNUT EXTRACT; INFLAMMATORY GENE-EXPRESSION; CARBOHYDRATE OVERLOAD; LAMINAR TISSUE; DIGITAL HYPOTHERMIA; IN-VIVO; HORSES; ACTIVATION; MODEL; LIPOPOLYSACCHARIDE;

D O I：

10.1007/s00441-018-2788-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Equine laminitis is a devastating disease in which failure of the adhesion between the digital dermal and epidermal laminae at the basement membrane results in crippling lameness and structural damage to the foot of the horse. Laminitis occurring secondary to sepsis is known to result from a significant inflammatory response that includes leukocyte emigration into the lamellar tissue. These leukocytes, in particular the neutrophil, have been extensively evaluated in experimental models of sepsis-related laminitis in the horse. This review will discuss the relevant findings elucidated from these models and how these findings have affected the development of therapies used to treat this crippling disease.

引用

页码：541 / 550

页数：10

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