Hepatitis C virus and the brain

被引：87

作者：

Fletcher, N. F. ^{[1
]}

McKeating, J. A. ^{[1
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, Hepatitis C Res Grp, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF VIRAL HEPATITIS | 2012年 / 19卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

blood-brain barrier; central nervous system; hepatitis C; human immunodeficiency virus; reservoir; CENTRAL-NERVOUS-SYSTEM; HIV-INFECTED INDIVIDUALS; LIVER-TRANSPLANTATION; CEREBROSPINAL-FLUID; REPLICATION; ACTIVATION; CELLS; COINFECTION; SEQUENCES; NEUROINFLAMMATION;

D O I：

10.1111/j.1365-2893.2012.01591.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

. Hepatitis C virus (HCV) is an enveloped, positive-strand RNA virus of the family Flaviviridae that primarily infects hepatocytes, causing acute and chronic liver disease. HCV is also associated with a variety of extrahepatic symptoms including central nervous system (CNS) abnormalities, cognitive dysfunction, fatigue and depression. These symptoms do not correlate with the severity of liver disease and are independent of hepatic encephalopathy. HCV RNA has been associated with CNS tissue, and reports of viral sequence diversity between brain and liver tissue suggest independent viral evolution in the CNS and liver. This review will explore the data supporting HCV infection of the CNS and how this fits into our current understanding of HCV pathogenesis.

引用

页码：301 / 306

页数：6

共 54 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[2] The neuropathology of HIV/AIDS [J].

Anthony, I. C. ;

Bell, J. E. .

INTERNATIONAL REVIEW OF PSYCHIATRY, 2008, 20 (01) :15-24

[3] Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy [J].

Bokemeyer, M. ;

Ding, X-Q ;

Goldbecker, A. ;

Raab, P. ;

Heeren, M. ;

Arvanitis, D. ;

Tillmann, H. L. ;

Lanfermann, H. ;

Weissenborn, K. .

GUT, 2011, 60 (03) :370-377

[4] PCR detected hepatitis C virus genome in the brain of a case with progressive encephalomyelitis with rigidity [J].

Bolay, H ;

Soylemezoglu, F ;

Nurlu, G ;

Tuncer, S ;

Varli, K .

CLINICAL NEUROLOGY AND NEUROSURGERY, 1996, 98 (04) :305-308

[5] Hepatitis C virus enters human peripheral neuroblastoma cells - evidence for extra-hepatic cells sustaining hepatitis C virus penetration [J].

Buergel, B. ;

Friesland, M. ;

Koch, A. ;

Manns, M. P. ;

Wedemeyer, H. ;

Weissenborn, K. ;

Schulz-Schaeffer, W. J. ;

Pietschmann, T. ;

Steinmann, E. ;

Ciesek, S. .

JOURNAL OF VIRAL HEPATITIS, 2011, 18 (08) :562-570

[6] Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition [J].

Byrnes, Valerie ;

Miller, Anne ;

Lowry, Damien ;

Hill, Erin ;

Weinstein, Cheryl ;

Alsop, David ;

Lenkinski, Robert ;

Afdhal, Nezam H. .

JOURNAL OF HEPATOLOGY, 2012, 56 (03) :549-556

[7] Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex [J].

Chang, L ;

Ernst, T ;

Leonido-Yee, M ;

Walot, I ;

Singer, E .

NEUROLOGY, 1999, 52 (01) :100-108

[8] Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients [J].

Clifford, D. B. ;

Smurzynski, M. ;

Park, L. S. ;

Yeh, T. -M. ;

Zhao, Y. ;

Blair, L. ;

Arens, M. ;

Evans, S. R. .

NEUROLOGY, 2009, 73 (04) :309-314

[9] Plasma cytokine concentrations associated with HIV/hepatitis C coinfection are related to attention, executive and psychomotor functioning [J].

Cohen, Ronald A. ;

de la Monte, Suzanne ;

Gongvatana, Assawin ;

Ombao, Hernando ;

Gonzalez, Beverly ;

Devlin, Kathryn N. ;

Navia, Bradford ;

Tashima, Karen T. .

JOURNAL OF NEUROIMMUNOLOGY, 2011, 233 (1-2) :204-210

[10] Second hepatitis C replication compartment indicated by viral dynamics during liver transplantation [J].

Dahari, H ;

Feliu, A ;

Garcia-Retortillo, M ;

Forns, X ;

Neumann, AU .

JOURNAL OF HEPATOLOGY, 2005, 42 (04) :491-498

← 1 2 3 4 5 6 →