Stereoselective bioreduction of bulky-bulky ketones by a novel ADH from Ralstonia sp.

被引：106
作者：
Lavandera, Ivan
Kern, Alexander [2 ]
Ferreira-Silva, Bianca [1 ]
Glieder, Anton [2 ]
de Wildeman, Stefaan [3 ]
Kroutil, Wolfgang [1 ]
机构：
[1] Graz Univ, Res Ctr Appl Biocatalysis, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria
[2] Graz Univ Technol, Res Ctr Appl Biocatalysis, Inst Mol Biotechnol, A-8010 Graz, Austria
[3] DSM Pharmaceut Prod, NL-6160 MD Geleen, Netherlands
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 15期
关键词：
D O I：
10.1021/jo800849d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ketones with two bulky substituents, named bulky-bulky ketones, as well as less sterically demanding ketones were successfully reduced to the corresponding optically highly enriched alcohols using a novel identified recombinant short-chain alcohol dehydrogenase RasADH from Ralstonia sp. DSM 6428 overexpressed in E. coli.
引用
收藏
页码：6003 / 6005
页数：3
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