Carlina Oxide - A Natural Polyacetylene from Carlina acaulis (Asteraceae) with Potent Antitrypanosomal and Antimicrobial Properties

被引：50

作者：

Herrmann, Florian ^{[1
]}

Hamoud, Razan ^{[1
]}

Sporer, Frank ^{[1
]}

Tahrani, Ahmed ^{[1
]}

Wink, Michael ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

来源：

PLANTA MEDICA | 2011年 / 77卷 / 17期

关键词：

Carlina acaulis; Asteraceae; Carlina oxide; Trypanosoma brucei brucei - MRSA; cytotoxicity; HUMAN AFRICAN TRYPANOSOMIASIS; ROOT ESSENTIAL OIL; GLUTATHIONE-REDUCTASE; IN-VITRO; TRYPANOTHIONE; RHODESIENSE; DISCOVERY; GAMBIENSE; PRODUCTS; COFACTOR;

D O I：

10.1055/s-0031-1279984

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Carlina acaulis (Asteraceae) has a long history of medicinal use in Europe due to its antimicrobial properties. The strong activity of Carlina oxide, the main compound of the essential oil of C. acaulis against two MRSA strains, Streptococcus pyogenes, Pseudomonas aeruginosa, Candida albicans, and C. glabrata was confirmed. A strong and selective activity against Trypanosoma brucei brucei with an IC(50) of 1.0 mu g/mL and a SI of 446 compared to human HeLa cells was recorded. The selective toxicity of Carlina oxide makes it a promising lead compound for the development of drugs to treat African trypanosomiasis and multiresistant gram-positive bacteria.

引用

页码：1905 / 1911

页数：7

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