Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

被引:23
作者
Diot, Quentin [1 ]
Kavanagh, Brian [1 ]
Timmerman, Robert [2 ]
Miften, Moyed [1 ]
机构
[1] Univ Colorado, Sch Med, Dept Radiat Oncol, Aurora, CO 80045 USA
[2] Univ Texas SW Med Sch, Dept Radiat Oncol, Dallas, TX 75390 USA
关键词
VMAT; SBRT; lung; liver; prostate; biological-based optimization; RADIOTHERAPY; PROSTATE; IMRT; INDEX;
D O I
10.1118/1.3668059
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment delivery times. (C) 2012 American Association of Physicists in Medicine. [DOI: 10.1118/1.3668059]
引用
收藏
页码:237 / 245
页数:9
相关论文
共 50 条
[41]   Plan Complexity and Delivery Accuracy of Knowledge-based Volumetric Modulated Arc Therapy Plans with Single Optimization for Oropharyngeal Cancer [J].
Okuhata, Katsuya ;
Monzen, Hajime ;
Tamura, Mikoto ;
Matsumoto, Kenji ;
Otsuka, Masakazu ;
Kubo, Kazuki ;
Ueda, Yoshihiro ;
Uehara, Takuya ;
Doi, Hiroshi ;
Ishikawa, Kazuki ;
Nishimura, Yasumasa .
ANTICANCER RESEARCH, 2021, 41 (06) :2925-2931
[42]   CLINICAL APPLICATIONS OF VOLUMETRIC MODULATED ARC THERAPY [J].
Matuszak, Martha M. ;
Yan, Di ;
Grills, Inga ;
Martinez, Alvaro .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 77 (02) :608-616
[43]   Comparison of plan optimization for single and dual volumetric-modulated arc therapy versus intensity-modulated radiation therapy during post-mastectomy regional irradiation [J].
Zhao, Li-Rong ;
Zhou, Yi-Bing ;
Sun, Jian-Guo .
ONCOLOGY LETTERS, 2016, 11 (05) :3389-3394
[44]   Minimizing dose variation from the interplay effect in stereotactic radiation therapy using volumetric modulated arc therapy for lung cancer [J].
Kubo, Kazuki ;
Monzen, Hajime ;
Tamura, Mikoto ;
Hirata, Makoto ;
Ishii, Kentaro ;
Okada, Wataru ;
Nakahara, Ryuta ;
Kishimoto, Shun ;
Kawamorita, Ryu ;
Nishimura, Yasumasa .
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 2018, 19 (02) :121-127
[45]   Radiation therapy of anal canal cancer: from conformal therapy to volumetric modulated arc therapy [J].
Angelo Tozzi ;
Luca Cozzi ;
Cristina Iftode ;
Annamaria Ascolese ;
Maria Concetta Campisi ;
Elena Clerici ;
Tiziana Comito ;
Fiorenza De Rose ;
Antonella Fogliata ;
Ciro Franzese ;
Pietro Mancosu ;
Piera Navarria ;
Stefano Tomatis ;
Elisa Villa ;
Marta Scorsetti .
BMC Cancer, 14
[46]   Radiation therapy of anal canal cancer: from conformal therapy to volumetric modulated arc therapy [J].
Tozzi, Angelo ;
Cozzi, Luca ;
Iftode, Cristina ;
Ascolese, Annamaria ;
Campisi, Maria Concetta ;
Clerici, Elena ;
Comito, Tiziana ;
De Rose, Fiorenza ;
Fogliata, Antonella ;
Franzese, Ciro ;
Mancosu, Pietro ;
Navarria, Piera ;
Tomatis, Stefano ;
Villa, Elisa ;
Scorsetti, Marta .
BMC CANCER, 2014, 14
[47]   Stereotactic ablative radiation therapy for brain metastases with volumetric modulated arc therapy and flattening filter free delivery: feasibility and early clinical results [J].
Alba Fiorentino ;
Niccolò Giaj-Levra ;
Umberto Tebano ;
Rosario Mazzola ;
Francesco Ricchetti ;
Sergio Fersino ;
Gioacchino Di Paola ;
Dario Aiello ;
Ruggero Ruggieri ;
Filippo Alongi .
La radiologia medica, 2017, 122 :676-682
[48]   Stereotactic ablative radiation therapy for brain metastases with volumetric modulated arc therapy and flattening filter free delivery: feasibility and early clinical results [J].
Fiorentino, Alba ;
Giaj-Levra, Niccolo ;
Tebano, Umberto ;
Mazzola, Rosario ;
Ricchetti, Francesco ;
Fersino, Sergio ;
Di Paola, Gioacchino ;
Aiello, Dario ;
Ruggieri, Ruggero ;
Alongi, Filippo .
RADIOLOGIA MEDICA, 2017, 122 (09) :676-682
[49]   Direct leaf trajectory optimization for volumetric modulated arc therapy planning with sliding window delivery [J].
Papp, David ;
Unkelbach, Jan .
MEDICAL PHYSICS, 2014, 41 (01)
[50]   Stereotactic body radiation therapy for prostate cancer: a study comparing 3-year genitourinary toxicity between CyberKnife and volumetric-modulated arc therapy by propensity score analysis [J].
Ito, Makoto ;
Yoshioka, Yasuo ;
Takase, Yuuki ;
Suzuki, Junji ;
Takahashi, Hironori ;
Minami, Yoshitaka ;
Sakuragi, Ami ;
Oshima, Yukihiko ;
Okuda, Takahito ;
Suzuki, Kojiro .
RADIATION ONCOLOGY, 2023, 18 (01)