Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

被引：33

作者：

Allen, Joseph C. ^{[1
]}

Kociok-Koehn, Gabriele ^{[1
]}

Frost, Christopher G. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 01期

关键词：

ASYMMETRIC 1,4-ADDITION; LIGANDS; REAGENTS; ACID; ORGANOBORON; DERIVATIVES; STRATEGY; OLEFINS; ROUTE;

D O I：

10.1039/c1ob06586f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.

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页码：32 / 35

页数：4

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