Rhodium-catalysed enantioselective synthesis of 4-arylchroman-2-ones

被引：33
作者：
Allen, Joseph C. [1 ]
Kociok-Koehn, Gabriele [1 ]
Frost, Christopher G. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 01期
关键词：
ASYMMETRIC 1,4-ADDITION; LIGANDS; REAGENTS; ACID; ORGANOBORON; DERIVATIVES; STRATEGY; OLEFINS; ROUTE;
D O I：
10.1039/c1ob06586f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The rhodium-catalysed enantioselective 1,4-addition of organoboron reagents to arylidene Meldrum's acids as acceptors, allows convenient access to 4-arylchroman-2-ones with good to excellent levels of enantioselectivity. The use of silyl-protected dioxaborinanes as donors was found to be advantageous to achieving good yields of product under anhydrous conditions.
引用
收藏
页码：32 / 35
页数：4
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