Differentiation and apoptosis of neuroblastoma cells: Role of N-myc gene product

被引：0
|
作者：
Galderisi, U
Di Bernardo, G
Cipollaro, M
Peluso, G
Cascino, A
Cotrufo, R
Melone, MAB
机构：
[1] CRISCEB, I-80100 Naples, Italy
[2] Univ Naples 2, Sch Med, Inst Neurol, I-80100 Naples, Italy
[3] CNR, Inst Biochem Technol & Enzymol, I-80078 Naples, Italy
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 1999年 / 73卷 / 01期
关键词：
N-myc; apoptosis; differentiation; neuroblastoma;
D O I：
10.1002/(SICI)1097-4644(19990401)73:1<97::AID-JCB11>3.0.CO;2-M
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To clarify the role and function of the N-myc product in cell differentiation and apoptosis, we used the antisense oligonucleotide technique to inhibit N-myc gene expression in neuroblastoma cells with different phenotypes: intermediate (I) and neuronal (N), or Schwann-glia (S), respectively. The results suggest that N-myc operates along different pathways. Inhibiting N-myc gene expression either results in suppression of cell proliferation or in induction of differentiation and/or apoptosis. J. Cell. Biochem. 73:97-105, 1999. (C) 1999 Wiley-Liss, Inc.
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页码：97 / 105
页数：9
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