Chemistry of antipyrine

被引：37
作者：
Elattar, Khaled M. [1 ]
Fadda, Ahmed A. [1 ]
机构：
[1] Mansoura Univ, Dept Chem, Fac Sci, El Gomhoria St, Mansoura 35516, Egypt
来源：
SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 19期
关键词：
Antipyrine; reactions; synthesis; synthetic and biological importance; HETEROCYCLIC SYNTHESIS SYNTHESIS; PHOTOCHEMICAL DECOMPOSITION; PHENAZONE DERIVATIVES; AROMATIC-ALDEHYDES; COLOR-REACTION; ACID; ENAMINONITRILES; CORROSION; PYRAZOLE; ACCESS;
D O I：
10.1080/00397911.2016.1211703
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This review is a literature survey of antipyrine, considered as one of the most valuable compounds in the fields of organic and medicinal chemistry. The biological importance, synthetic procedures, and reactions are discussed. Generally, the preparation of antipyrine was reported through the methylation of the corresponding 1H-pyrazolone following different reaction conditions. The reactions, in general, are electrophilic substitutions at C-4-position of pyrazolone. The mechanistic pathways of the reactions are surveyed. [GRAPHICS] .
引用
收藏
页码：1567 / 1594
页数：28
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