DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health

被引：23

作者：

Mur, Jure ^{[1
,2
]}

McCartney, Daniel L. ^{[2
]}

Walker, Rosie M. ^{[2
]}

Campbell, Archie ^{[2
]}

Bermingham, Mairead L. ^{[2
]}

Morris, Stewart W. ^{[2
]}

Porteous, David J. ^{[2
]}

McIntosh, Andrew M. ^{[2
,3
]}

Deary, Ian J. ^{[1
]}

Evans, Kathryn L. ^{[2
]}

Marioni, Riccardo E. ^{[2
]}

机构：

[1] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland

[3] Univ Edinburgh, Ctr Clin Brain Sci, Div Psychiat, Edinburgh, Midlothian, Scotland

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2020年 / 6卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Alzheimer's disease; APOE; biomarker; cardiovascular disease; cholesterol; DNA methylation; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-E POLYMORPHISM; GENE; ASSOCIATION; GENOTYPE; ANK1; AGE;

D O I：

10.1002/trc2.12026

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Genetic variation in the apolipoprotein E (APOE) gene is associated with Alzheimer's disease (AD) and risk factors for cardiovascular disease (CVD). DNA methylation at APOE has been associated with altered cognition and AD. It is unclear if epigenetic marks could be used for predicting future disease. Methods: We assessed blood-based DNA methylation at 13 CpGs in the APOE gene in 5828 participants from the Generation Scotland (GS) cohort. Using linear mixed models regression, we examined the relationships among APOE methylation, cognition, cholesterol, the family history of AD and the risk for CVD. Results: DNA methylation at two CpGs was associated with the ratio of total cholesterol and HDL cholesterol, but not with cognition, family history of AD, or the risk of CVD. Discussion: APOE methylation is associated with the levels of blood cholesterol, but there is no evidence for the utility of APOE methylation as a biomarker for predicting AD or CVD.

引用

页数：9

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