Pestalotheols E-H: Antimicrobial Metabolites from an Endophytic Fungus Isolated from the Tree Arbutus unedo

被引：14
作者：
Qin, Song [1 ,2 ]
Krohn, Karsten [1 ]
Hussain, Hidayat [1 ]
Schulz, Barbara [3 ]
Draeger, Siegfried [3 ]
机构：
[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany
[2] Nanjing Sanhome Pharmaceut Inst, Nanjing 210038, Peoples R China
[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrobiol, D-31806 Braunschweig, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 26期
关键词：
Natural products; Structure elucidation; Oxygen heterocycles; Biological activity;
D O I：
10.1002/ejoc.201100568
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four new compounds, pestalotheols E-H (1-4), along with one known metabolite, anofinic acid (5), were isolated from a fungal endophyte, an unidentified Ascomycete. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative stereochemistries of pestalotheols E-H (1-4) were confirmed by NOESY experiments. Compounds 1-5 showed good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca; compounds 3-5 showed strong antibacterial activity.
引用
收藏
页码：5163 / 5166
页数：4
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