Pestalotheols E-H: Antimicrobial Metabolites from an Endophytic Fungus Isolated from the Tree Arbutus unedo

被引：14

作者：

Qin, Song ^{[1
,2
]}

Krohn, Karsten ^{[1
]}

Hussain, Hidayat ^{[1
]}

Schulz, Barbara ^{[3
]}

Draeger, Siegfried ^{[3
]}

机构：

[1] Univ Paderborn, Dept Chem, D-33098 Paderborn, Germany

[2] Nanjing Sanhome Pharmaceut Inst, Nanjing 210038, Peoples R China

[3] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrobiol, D-31806 Braunschweig, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 26期

关键词：

Natural products; Structure elucidation; Oxygen heterocycles; Biological activity;

D O I：

10.1002/ejoc.201100568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new compounds, pestalotheols E-H (1-4), along with one known metabolite, anofinic acid (5), were isolated from a fungal endophyte, an unidentified Ascomycete. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative stereochemistries of pestalotheols E-H (1-4) were confirmed by NOESY experiments. Compounds 1-5 showed good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca; compounds 3-5 showed strong antibacterial activity.

引用

页码：5163 / 5166

页数：4

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